생명과학연구소 제551회 정기세미나_장재락 교수님(아주대)

Autophagic clearance of protein aggregates associated with neurodegenerative diseases

장재락 교수(아주대학교 의과대학)

Accumulation of various types of abnormal/unwanted intracellular substances is one of the main causes of the development of neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. Autophagy is a fundamental intracellular process for clearance of unwanted or damaged materials accumulated in the cell. The autophagic process is initiated by the formation of phagophore mediated by sequential recruitment of specific protein complexes. The phagophore matures into the autophagosome which engulfs autophagic cargos such as cytoplasmic proteins and organelles. Autophagy is finally completed by the degradation of the materials at the autolysosome which is formed by the fusion of the autophagosome and the lysosome. Tripartite motif (TRIM) proteins are a subfamily of the RING-type E3 ubiquitin ligase family and various functional domains of TRIM proteins including the RING domain enable the proteins to play critical roles in a wide range of biological processes. In this presentation, I will discuss the roles of a TRIM protein in autophagic clearance which might be linked to the onset or progression of neurodegenerative diseases.

학력 및 약력

2002                   B.S. School of Biological Sciences, Seoul National University

2009                   Ph.D. School of Biological Sciences, Seoul National University, Korea

2010-2011          Visiting Fellow, National Cancer Institute/NIH, Bethesda, MD, USA

2011-2016          Visiting Fellow/Research Fellow, National Institute of Neurological Disorders and Stroke/ NIH, USA

2016-present       Assistant, Associate Professor, Ajou University School of Medicine, Suwon, Korea

주요발표논문 (최근)

1. Identification of Cathepsin D as a Plasma Biomarker for Alzheimer's Disease. Kim JW*, Jung SY*, Kim Y, Heo H, Hong CH, Seo SW, Choi SH, Son SJ, Lee S, Chang J. Cells. 2021 Jan 12;10(1):E138. doi: 10.3390/cells10010138.

2. Identification of BAG2 and Cathepsin D as Plasma Biomarkers for Parkinson's Disease. Kang J*, Kim JW*, Heo H, Lee J, Park KY, Yoon JH, Chang J. Clin Transl Sci. 2021 Mar;14(2):606-616. doi: 10.1111/cts.12920. Epub 2020 Nov 22.

3. Hereditary spastic paraplegia SPG8 mutations impair CAV1-dependent, integrin-mediated cell adhesion. Lee S*, Park H, Zhu PP, Jung SY, Blackstone C, Chang J. Sci Signal. 2020 Jan 7;13(613):eaau7500. doi: 10.1126/scisignal.aau7500. Selected as a cover paper of the issue.

4. Cerebrospinal Fluid Levels of β-Amyloid 40 and β-Amyloid 42 are Proportionately Decreased in Amyloid Positron-Emission Tomography Negative Idiopathic Normal-Pressure Hydrocephalus Patients. Kim HJ*, Lim TS, Lee SM, Kim TS, Kim Y, An YS, Youn YC, Park SA, Chang J, Moon SY. J Clin Neurol. 2019 Jul;15(3):353-359. doi: 10.3988/jcn.2019.15.3.353.

5. Lung fibroblasts may play an important role in clearing apoptotic bodies of bronchial epithelial cells generated by exposure to PHMG-P-containing solution. Park EJ*, Park SJ, Kim S, Lee K, Chang J. Toxicol Lett. 2018 Apr;286:108-119. doi: 10.1016/j.toxlet.2018.01.003. Epub 2018 Jan 5.

6. Methylisothiazolinone may induce cell death and inflammatory response through DNA damage in human liver epithelium cells. Park EJ*, Kim S, Chang J. Environ Toxicol. 2018 Feb;33(2):156-166. doi: 10.1002/tox.22503. Epub 2017 Nov 7.