430회 R/BCD, Research/Business & Connective Development)에 의한 바이오 연구

430회  (2009. 11. 12.)

연사:  오 태 광,  한국생명공학연구원

제목:  R/BCD (Research/Business & Connective Development)에 의한 바이오 연구  

Abstract 

The new millenium is the era of biotechnology and life sciences. With the development of high throughput technologies, systematic approachs and related fusion technologies such as BIT, BNT, BET,BMT and BCT and so on, the capacity to decipher genome sequences and to make the useful informations rapidly increased during the last decade. In addition, new technologies including microarray chips, microfluidics and system biological analysis are enabling us to study expression of all the genes and proteins in a cell, thus resulting in new research areas and terms often ending with "- ome" and "-omics". For the industrial use of genome technologies such as gene manipulations, genomic designs, and redesigned microbes, GMO controls for the environmental safety is focusing on obstacles of bioindustrial developments. Currently, more than 1,112 microbial genomes have been published complete genomes  and 3,000 more are being analyzed. The sequence information of a newly determined genome is often not released to the public anymore due to intellectual property issues and possible industrial applications. The future of biotechnology research and development will depend upon an integrative approach, combining an understanding of the genetic makeup of living cells (genomics) along with the diversity of proteins (proteomics), as well as the function and interaction of these biomolecules and their contribution to the phenotypic outcome (phenomics), including their involvement in metabolic pathway regulation and control (metabolomics).  From these view, Biodiversities including new living cells and metagenomics will trigger to open gates of future biotechnology. These "-omics" investigations will lead to an understanding of the molecular basis of the cell, how its different components interact and influence the cell's biological pathways, physiology, and structure, and how  the cell's genes and proteins operate in real time to regulate and control development and differentiation, as well as cell death. Understanding how these processes interact to form a living cell will require a unified "systems biology" effort that incorporates: the cataloging, annotation, and curation of all "-omic" information, in a format that allows interoperative queries (bioinformatics); the identification and characterization of all molecular constituents (function); the measurement and statistical analysis of all molecular processes (physiometrics); and the quantification of the relationships between phenotypes and genotype (modeling). And finally, all "-omics" technologies will promise new gengeration of biotechnolgies including Biotechnology based IT, NT,ET,MT and CT fusion technologies in the furture.  The Microbial Genomics and Applications Center (MGAC) sponsored  by  Korean Ministry of Education, Science and Technology is focused on developing a technology platform to utilized the information on genomic functions resulting from the analyses of microbial genomes isolated from diverse natural environments to promote the discovery of novel genes, valuable biomolecules, engineered microbes, and innovative bioprocesses. For the effective research in our fields, Research and Business Connective Development (R/BCD) was adapted by analysis of papers, patents, and market based on technical evaluations.   

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