제 546회 생명과학연구소 정기세미나_김대희, 차병현 교수님 (강원대)

일시: 2021년 9월 16일(목) 오후5시

장소: 의생명과학대학 B동 128호

온라인:https://kangwon-ac-kr.zoom.us/j/83900927310?pwd=ZCtFQlczZHhSYjJ5OHNhVDhLdlVQUT09

The pursuit of therapeutic antibody development and its’ uncertain functionality

김대희 교수(강원대학교 약학대학)

In pursuit of the development of effective tools and biological drugs, ‘antibody’ has been a comprehensive and powerful entity in biomedical R&D area for decades. For validated disease targets, especially for the ones at extracellular region, antibody has been a top priority drug to control such disease and there have been a lot of antibody drug development trials. For non-validated targets, novel antibody could be an informative tool to study the biology of the target molecule. Phage display technology has become a well-established platform to isolate such antibodies against several targets. With accumulated evidences on the important relationship between antibody’s functionality and its’ binding epitope on antigen, deliberate selection strategy and functional assay also became much important parts of the antibody developments. Two aspects of antibody developments will be discussed in the talk with examples of recent anti-MUC1 antibody and anti-PD-L1 antibody developments.

학력 및 약력

1990-1994   연세대학교 화학과 (B.S.)

1994-1996   KAIST 화학과 (M.S.)

1996-2001   KAIST 화학과 (Ph.D.)

2001-2005   ISU ABXIS (Biotech Co. Korea)

2005-2009   The Scripps Research Inistitute (Post Doctoral Research Associate)

2009-2020  Scripps Korea Antibody Institute (Principle Investigator)

2016-2020  Scripps Korea Antibody Institute (Directior of Research Division)

2021-현재 강원대학교 약학대학 조교수

Physicochemical interaction between stem cell and biomaterial for clinical application

차병현 교수(강원대학교 의생명융합학부)

Pluripotent stem cells (PSCs) such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are a potent source of clinically relevant mesenchymal stem cells (MSCs) that confer functional and structural benefits in cell therapy and tissue regeneration. Obtaining sufficient numbers of MSCs in a short period of time and enhancing the differentiation potential of MSCs can be offered the potential to improve the regenerative activity of MSCs therapy. In addition, the underlying processes in the isolation and derivation of MSCs from hPSCs are still poorly understood and controlled. Recently, much of paper reported that understanding the biophysical relationships between stem cells and applied biomaterials can facilitate the ability to control the functions and behaviors of stem cells. However, the role of biophysical interaction between stem cells (cells) and applied biomaterials in stem cell biology remains largely unexplored. In here, we would like to share two research topics. First, an efficient and simplified technique that improves the isolation efficacy the of MSCs from spontaneously differentiated human ESCs via integrin