364회 Functional Genomics of Vibrio vulnificus: from Survival to Toxige…

364회

연사 :  최 상 호, 서울대학교 농업생명과학대학 식품공학과

제목:  Functional Genomics of Vibrio vulnificus: from Survival to Toxigenesis

Abstract

 Understanding the molecular pathogenesis of the multifaceted host-pathogen interaction is critical in the development of improved treatment and prevention, as well as elucidating how certain bacteria can circumvent host defenses, multiply in the host, and cause such extensive damage. Disease caused by infection with V. vulnificus is remarkable for the invasive nature of the infection, ensuing severe tissue damage, and rapidly fulminating course.  The characterization of somatic as well as secreted products of V. vulnificus has yielded a large list of putative virulence attributes, whose known functions are easily imagined to explain the pathology of disease.  These putative virulence factors include a carbohydrate capsule, lipopolysaccharide, a cytolysin/hemolysin, elastolytic metalloprotease, iron sequestering systems, lipase, and pili.  However, only few among the putative virulence factors has been confirmed to be essential for virulence by the use of molecular Kochs postulates. This presentation describes molecular biological characterization of the virulence factors contributing to survival as well as to toxigenesis of V. vulnificus.