363회 Ginsenoside Rg3 enhances the expression of type A macrophage scav…

363회

연사 :  주 성 수, 중앙대학교 약학대학 생명의학연구원

제목:  Ginsenoside Rg3 enhances the expression of type A macrophage scavenger receptor and phagocytosis of rat microglia

Abstract

 Macrophage scavenger receptors (MSRs) induce microglial interaction with β-amyloid fibrils (fAβ) that are associated with Alzheimers disease (AD). Although microglia are known to have reciprocal effects in the AD brain, formation of plaque and clearance of fAβ, receptor-mediated phagocytosis is a very important tool for preventing amyloid plaque via activated microglia in the earlier stage of AD. We report here that ginsenoside Rg3 increased the expression of type-A MSR (MSR-A) in microglia and thus accelerated the phagocytosis with an effective degradation of engulfed fAβ. This result suggested that pre-treatment with Rg3 may play an important role in removing fAβ by enhancing the receptor-mediated phagocytosis. In addition, Rg3 could be a potential candidate for balancing the rate of production of fAβ in AD brain.