398회 Bioinformatics: Toward revealing secrets of the human genome.

398회  

일시: 2006. 12. 06

연사: 최선심, 강원대학교 BT특성화학부(대학) 생명공학부

제목: Bioinformatics: Toward revealing secrets of the human genome.

Abstract

Completion of the human genome sequencing induced a paradigm shift in biological research. Since the draft human genome sequence was published in 2001, many other genomes from lower organisms to higher organisms including several primates have been sequenced. The next step should be exploring the secrets of genomes. Here, I will briefly demonstrate how computer skills can be applied to the genome analyses. Further, I will introduce some of my studies of the human genome analyses through bioinformatics. First, using noncoding conservation as a proxy for the complexity of cis-regulatory DNA, it is shown that different classes of genes tend to have different levels of cis-regulatory complexity and that greater complexity can be found in genes involved in tissue-specific transcriptional regulation. Next, through a novel methodology called phylogeny-aided structural analysis, I will demonstrate that there are robust signals of interacting residue coevolution in mammalian proteomesathogens.