404회 Molecular Network in Osteoimmunology.

404회

연사 : 이 수 영, 이화여자대학교 자연대학 생명과학전공

제목:  Molecular Network in Osteoimmunology.

Abstract

Studies of bone and the immune system have converged in recent years under the banner of osteoimmunology. The immune system is spawned in the bone marrow reservoir and it is now recognized that important niches also exist there for memory lymphocytes. At the same time, various factors produced during immune responses are capable of profoundly affecting regulation of bone. Mechanisms have evolved to prevent excessive interference by the immune system with bone homeostasis, yet pathologic bone loss is a common sequelaassociated with autoimmunity and cancer. There are also developmental links, or parallels, between bone and the immune system. Cells that regulate bone turnover share a common precursor with inflammatory immune cells and may restrict themselves anatomically, in part by utilizing a signaling network analogous to lymphocyte costimulation. Efforts are currently underway to further characterize how these two organ systems overlap, and to develop therapeutic strategies which benefit from this understanding. Here we will present our recent effort how to develop new therapeutic targets tailored to increase the specificity toward the bone.