414회 A Systems Medicine Approach to Complex Human Diseases

414회 (2008. 4. 17.)

연사 : 황 대 희 교수, School of Interdisciplinary Bioscience and Bioengineering Department of Chemical Engineering, POSTECH

제목 : A Systems Medicine Approach to Complex Human Diseases

Abstract

 Living organisms execute their diverse functions by virtue of the operation of biological networks and their nodal components within or among cells.   Disease arises by genetic or environmental perturbations of one or more of these networks.  A systems view of disease attempts to understand the initiation and progression of disease in terms of their initial disease-perturbations and their dynamic transitions as disease progresses. Systems approaches to disease have two cardinal features:  1) global analyses to generate comprehensive data sets (e.g. how do all genes, mRNAs or proteins change upon perturbation or during transition) and 2) the integration of different levels of biological information (e.g. DNA, mRNA, protein, interactions, networks, tissues or organs, individuals, etc) to generate coherent hypotheses about health and disease. In this talk, I will present one of the first systems approaches to understanding a disease— prion infection in inbred strains of mice.  This approach transforms how one thinks about disease—explaining dynamic aspects of its pathophysiology and offering a new approach to early diagnostics.