429회 Mycobacterium avium subsp. paratuberculosis and M. abscessus: Eme…

429회  (2010. 10. 15.)

연사:  신 성 재, Department of Microbiology, College of Medicine, Chungnam National University

제목:   Mycobacterium avium subsp. paratuberculosis and M. abscessus: Emerging pathogenic mycobacteria as representatives of slowly growing and rapidly growing nontuberculous mycobacteria  

Abstract 

As general features of mycobacterial infections, the following are well known: (1) The incubation period between infection and disease is variable, challenging epidemiological delineation of exposure; (2) disease is less common than aymptomic infection; (3) clinical disease is chronic; and (4) host factors (genetic and acquired) are critical in determining the progression from infection to clinical disease. In Korea, the next most commonly isolated mycobacterial pathogens after M. tuberculosis are M. avium complex (MAC) as and M. abscessus. Out of MAC, M. paratuberculosis has been mostly focused due to its zonootic potentiality in relation to Crohn's disease. The etiology of Crohn's disease still remains elusive but enticingly near to resolution. Consensus opinion is that Crohn's disease results from the interplay of host genetics and one or more environmental triggers. M. abscessus is rapidly growing mycobacterium (RGM) that has emerged as a significant pathogen in humans as well.  This microorganism causes skin and soft tissue infections as well as pulmonary infections.  Evidence regarding the role of M. paratuberculosis in Crohn's disease is complex and controversial due in part to the difficulty of detecting the organism, and the fact the humans likely are not its normal host, potentially resulting in abnormal pathogen behavior. Here, the contributions of M. paratuberculosis to Crohn's disease and recently raising M. abscessus-infections in Korea will be discussed epidemiologically by comparisons with other mycobacterial pathogens.     

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